ETIOLOGY AND EPIDEMIOLOGY OF CANINE ADENOVIRUS TYPE 1:
Canine adenovirus type 1 (CAV-1), a nonenveloped doublestranded DNA virus in the Adenoviridae family, is the cause of infectious canine hepatitis (ICH). CAV-1 is closely related genetically and antigenically to CAV-2. In addition to the domestic dog, CAV-1 also infects wolves, coyotes, foxes, bears, and marine mammals. The incidence of infectious canine hepatitis has decreased with vaccination, although sporadic cases are identified, particularly in unvaccinated or improperly vaccinated puppies imported from countries where the disease is more prevalent.