Archive | Drug Reviews

In this section we promote drugs and their effects by companies.

Amlodipine (besylate, mesylate or maleate, Istin) POM

Formulations: Oral: 5 mg, 10 mg tablets.   Action: Dihydropyridine calcium-channel blocker, with predominant action as a peripheral arteriolar vasculature, causing vasodilation and reducing afterload. Has mild negative inotropic and chronotropic effects, which are negligible at low doses. Use: Treatment of systemic hypertension in cats and appears to be safe even when there is concurrent […]

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Clindamycin – (Cleocin, Dalacinm, Antirobe, Clinacin, Clindacyl, Clindaseptin) POM-V

  Formulations: Oral: 25 mg, 75 mg, 150 mg, 300 mg capsules and tablets; 25 mg/ml solution. Action: Lincosamide antibiotic that binds to the 50S ribosomal subunit, inhibiting peptide bond formation. May be bactericidal or bacteriostatic depending on susceptibility. Use:  Bone and joint infections associated with Gram-positive bacteria, pyoderma, toxoplasmosis and infections associated with the oral […]

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Gentamicin (Garamycin, Easotic, Genta, Otomax, Tiacil, Genticin) POM-V, POM

Formulations: Injectable: 40 mg/ml solution for i.v., i.m., s.c. injection (human preparation), 100 mg/ml solution for i.v., i.m., s.c. injection (Genta). Ophthalmic/aural solution: 0.5% solution (Tiacil); 0.3% ophthalmic gel (Clinagel). Gentamicin is a component of some topical ear preparations. Action: Aminoglycosides inhibit bacterial protein synthesis and require an oxygen-rich environment to be effective, thus they are ineffective […]

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Amikacin – (Amikacin, Amikin) POM

Formulations: Injectable: 50 mg/ml, 250 mg/ml solutions.   Action: Aminoglycosides inhibit bacterial protein synthesis. They are bactericidal and their mechanism of killing is concentration dependent, leading to a marked post-antibiotic effect, allowing prolonged dosing intervals (which may reduce toxicity). Use: Active against many Gram-negative bacteria, Staphylococcus aureus and Nocardia spp., including some that may be […]

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Ampicillin – (Amfipen, Ampicaps, Ampicare, Duphacillin) POM-V

Formulations: Injectable: Ampicillin sodium 250 mg, 500 mg powders for reconstitution (human licensed product only); 150 mg/ml suspension, 100 mg/ml long-acting preparation. Oral: 500 mg tablets; 250 mg capsule.   Action: Binds to penicillin-binding proteins involved in bacterial cell wall synthesis, thereby decreasing cell wall strength and rigidity, affecting cell division, growth and septum formation. It acts […]

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