Formulations: Oral: 5 mg, 10 mg tablets. Action: Dihydropyridine calcium-channel blocker, with predominant action as a peripheral arteriolar vasculature, causing vasodilation and reducing afterload. Has mild negative inotropic and chronotropic effects, which are negligible at low doses. Use: Treatment of systemic hypertension in cats and appears to be safe even when there is concurrent […]
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Formulations: Oral: 25 mg, 75 mg, 150 mg, 300 mg capsules and tablets; 25 mg/ml solution. Action: Lincosamide antibiotic that binds to the 50S ribosomal subunit, inhibiting peptide bond formation. May be bactericidal or bacteriostatic depending on susceptibility. Use: Bone and joint infections associated with Gram-positive bacteria, pyoderma, toxoplasmosis and infections associated with the oral […]
Formulations: Injectable: 40 mg/ml solution for i.v., i.m., s.c. injection (human preparation), 100 mg/ml solution for i.v., i.m., s.c. injection (Genta). Ophthalmic/aural solution: 0.5% solution (Tiacil); 0.3% ophthalmic gel (Clinagel). Gentamicin is a component of some topical ear preparations. Action: Aminoglycosides inhibit bacterial protein synthesis and require an oxygen-rich environment to be effective, thus they are ineffective […]
Formulations: Injectable: 50 mg/ml, 250 mg/ml solutions. Action: Aminoglycosides inhibit bacterial protein synthesis. They are bactericidal and their mechanism of killing is concentration dependent, leading to a marked post-antibiotic effect, allowing prolonged dosing intervals (which may reduce toxicity). Use: Active against many Gram-negative bacteria, Staphylococcus aureus and Nocardia spp., including some that may be […]
Formulations: Injectable: Ampicillin sodium 250 mg, 500 mg powders for reconstitution (human licensed product only); 150 mg/ml suspension, 100 mg/ml long-acting preparation. Oral: 500 mg tablets; 250 mg capsule. Action: Binds to penicillin-binding proteins involved in bacterial cell wall synthesis, thereby decreasing cell wall strength and rigidity, affecting cell division, growth and septum formation. It acts […]